Opportunity Information: Apply for PAR 16 456
The Multi-Site Pilot and Feasibility Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R34) funding opportunity (PAR 16-456) is a National Institutes of Health (NIH) discretionary grant issued under the Collaborative Research on Addiction at NIH (CRAN) initiative, with the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) jointly leading the effort. Its central focus is not on inventing entirely new clinical treatments, but on figuring out how to implement what already works in real-world systems. In practical terms, the FOA supports early-stage, multi-site pilot and feasibility projects that develop and test interventions, models, and/or frameworks aimed at system-level implementation of evidence-based interventions, guidelines, or principles. The goal is to improve how substance use prevention and treatment services are delivered, adopted, maintained at high quality, and sustained over time across complex service settings and organizations.
This opportunity is designed to strengthen the implementation side of substance use prevention and treatment by examining system-level barriers and solutions. Rather than concentrating solely on individual behavior change, it emphasizes how policies, workflows, organizational practices, interagency coordination, and service delivery infrastructure influence whether evidence-based prevention and treatment approaches are actually used consistently and effectively. Projects supported by this FOA are expected to generate practical, testable insights about improving uptake (getting organizations and providers to use proven approaches), quality (ensuring they are delivered correctly and effectively), and sustainability (making sure improvements last beyond the study period). Because the mechanism is an R34, the intent is typically to support pilot work and feasibility testing that can de-risk and inform later, larger-scale implementation trials by refining methods, demonstrating practicality across sites, and producing preliminary data on implementation outcomes.
The FOA uses the NIH grant funding instrument and falls under the Education and Health activity category. It is associated with CFDA numbers 93.273 and 93.279, reflecting the involvement of NIH institutes that support addiction and alcohol-related research and implementation science. The listed award ceiling is $225,000, which signals that projects are meant to be tightly scoped pilot or feasibility studies rather than full-scale effectiveness trials. The original closing date listed for the opportunity was January 24, 2018, and the FOA creation date was September 30, 2016, indicating this was a time-limited solicitation from that period rather than an open-ended, always-available funding stream.
Eligibility is broad and intentionally inclusive of many types of organizations that operate or influence prevention and treatment systems. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, along with public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility includes Native American tribal governments that are federally recognized as well as Native American tribal organizations that are not federally recognized tribal governments, and the FOA also calls out additional eligible categories such as Indian/Native American Tribal Governments (Other than Federally Recognized). Housing-related public entities may apply as well, including public housing authorities and Indian housing authorities. On the nonprofit side, both 501(c)(3) organizations and nonprofits without 501(c)(3) status are eligible, as are for-profit organizations (other than small businesses) and small businesses, plus an “other” category that can capture additional qualifying applicants.
The announcement also highlights several specific institution types and community organizations as eligible or of interest, reflecting an emphasis on reaching diverse populations and system contexts. These include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). Faith-based or community-based organizations are explicitly included, along with eligible federal agencies and regional organizations, and U.S. territories or possessions. These eligibility details align with the FOA’s implementation focus, because system-level change often requires participation from the institutions that actually deliver services, train the workforce, or shape local policy and practice.
At the same time, the FOA places strict limits on foreign involvement. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible, and foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In other words, projects must be fully domestic in terms of applicant organization and project components, which keeps the work anchored in U.S. prevention and treatment systems and the specific service delivery and policy environments NIH intends to improve through this program.
Overall, this grant opportunity is best understood as an NIH implementation-science pilot mechanism aimed at improving how evidence-based substance use prevention and treatment interventions are put into practice at the system level across multiple sites. It supports practical, early-stage testing of strategies and frameworks that can increase adoption, improve delivery and quality, and make services more sustainable in real-world settings. The combination of a multi-site emphasis, a feasibility-oriented R34 structure, and broad eligibility across government, education, nonprofit, and community organizations signals a strong interest in projects that are both rigorous and grounded in the operational realities of prevention and treatment systems in the United States.Apply for PAR 16 456
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Multi-Site Pilot and Feasibility Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R34)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279.
- This funding opportunity was created on 2016-09-30.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01) Apply for PAR 16 455 Funding Number: PAR 16 455 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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| Use of Technology to Enhance Patient Outcomes and Prevent Illness (R01) Apply for PA 17 010 Funding Number: PA 17 010 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Nicotinic Immune Modulation in the Presence of HIV-1 Infection (R01) Apply for RFA DA 17 020 Funding Number: RFA DA 17 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Quality of Care and Quality of Life for Persons with Alzheimers Disease and Related Dementias at the End of Life (R01) Apply for PAS 17 027 Funding Number: PAS 17 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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