Opportunity Information: Apply for PA 18 074
The Behavioral and Integrative Treatment Development Program (R03 Clinical Trial Optional), Funding Opportunity Number PA-18-074, is a National Institutes of Health (NIH) discretionary grant opportunity designed to support small, focused research projects that can be finished within a two-year period. It uses the R03 mechanism, which generally fits early, discrete studies that generate preliminary data, refine methods, or test the practicality of a new approach before pursuing a larger-scale project. The funding is capped at $50,000 (award ceiling listed as 50000), and the opportunity is labeled "clinical trial optional," meaning applicants may propose a project that includes a clinical trial if appropriate, but a clinical trial is not required.
The program’s main goal is to stimulate early-stage (Stage I) development of behavioral or integrative interventions. "Integrative" here refers to approaches that combine behavioral strategies with other components, such as pharmacological treatment, in a coordinated way. The targeted problem areas are clearly defined: (a) substance abuse, (b) preventing the acquisition or transmission of HIV among people who are in drug abuse treatment, (c) improving adherence to drug abuse treatment as well as HIV and addiction medications, and (d) chronic pain. In practical terms, the FOA is looking for projects that build, refine, and test interventions that can change health-related behaviors and improve real-world outcomes for people affected by addiction, HIV risk in treatment settings, medication adherence challenges, and pain that may overlap with substance use concerns.
The FOA highlights several examples of the kinds of studies NIH wants to encourage, all centered on Stage I treatment development work. One major category is Stage I intervention generation, which is the initial creation of a new intervention or a meaningful adaptation of an existing one to a new population, setting, or delivery format. Another category is Stage I pilot or feasibility research, where the emphasis is on whether an intervention can be delivered as intended, whether participants will enroll and stay engaged, whether the procedures are workable, and whether outcome measures can be collected reliably. A notable expectation for these early projects is attention to the "how" and "why" of behavior change: applicants are encouraged to develop and test putative moderators (factors that influence for whom or under what conditions an intervention works), mediators (variables that help explain the pathway from intervention to outcome), and other candidate mechanisms of change. The FOA also calls out Stage I studies aimed at generating or refining drug abuse treatment and adherence interventions specifically, as well as Stage I research focused on strengthening intervention effects and increasing implementability. That last theme explicitly encourages creative use of technology or other methods to make interventions easier to deliver, more scalable, and more likely to be adopted in real clinical or community settings.
Eligibility is broad and includes many types of organizations that can contribute to behavioral health and intervention development research. Eligible applicants include state, county, city, township, and special district governments; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education and private institutions of higher education; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those specific nonprofit categories); for-profit organizations (other than small businesses) and small businesses; and an "other" category. The FOA also specifically highlights additional eligible groups and settings such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities. Taken together, this signals NIH interest in diverse institutional participation and in interventions that may be relevant across different communities and service systems.
In terms of basic administrative details provided in the source data, the sponsoring agency is NIH, and the activity aligns with the education and health funding category. The CFDA numbers listed are 93.273 and 93.279. The record shows an original closing date of 2019-01-07 and a creation date of 2017-11-02, indicating this particular posting reflects that application window. Overall, the opportunity is best understood as a small-grant pathway for researchers who want to quickly and rigorously develop, adapt, and pilot promising behavioral or combined behavioral-pharmacological interventions in substance use, HIV prevention in treatment contexts, treatment and medication adherence, and chronic pain, while also building the early evidence base about mechanisms and practical implementation.Apply for PA 18 074
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Behavioral and Integrative Treatment Development Program (R03 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279.
- This funding opportunity was created on 2017-11-02.
- Applicants must submit their applications by 2019-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is the Behavioral and Integrative Treatment Development Program (R03 Clinical Trial Optional).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-18-074.
Which federal agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is used?
This opportunity uses the NIH R03 mechanism, which is intended for small, focused research projects.
What is the main purpose of the R03 in this program?
The program is designed to support early, discrete studies that generate preliminary data, refine methods, or test the practicality of a new approach before pursuing a larger-scale project.
How long can an R03 project last under this opportunity?
Projects are intended to be finished within a two-year period.
What is the maximum funding available?
The funding cap (award ceiling) is $50,000.
Is a clinical trial required?
No. The FOA is labeled "clinical trial optional," meaning a clinical trial may be included if appropriate, but it is not required.
What does "clinical trial optional" mean in practical terms?
Applicants may propose a project that includes a clinical trial if it fits the research aims, but applicants can also propose non-trial studies that focus on intervention development, adaptation, feasibility, or related early-stage work.
What is the program trying to stimulate or advance?
The program’s main goal is to stimulate early-stage (Stage I) development of behavioral or integrative interventions.
What does "Stage I" mean in this context?
Stage I refers to early treatment development work, such as creating or adapting an intervention and conducting pilot/feasibility research to assess practicality, delivery, engagement, and measurement.
What counts as a "behavioral" intervention for this program?
The FOA focuses on interventions that aim to change health-related behaviors and improve real-world outcomes in the targeted problem areas (for example, substance abuse, adherence, and HIV risk in treatment settings).
What does "integrative" mean in this FOA?
"Integrative" refers to approaches that combine behavioral strategies with other components (such as pharmacological treatment) in a coordinated way.
What problem areas are specifically targeted?
The FOA identifies four targeted areas: (a) substance abuse, (b) preventing the acquisition or transmission of HIV among people who are in drug abuse treatment, (c) improving adherence to drug abuse treatment and to HIV and addiction medications, and (d) chronic pain.
Are projects required to fit one of the listed problem areas?
Yes. The FOA describes these problem areas as clearly defined targets for the intervention development work it aims to support.
What kinds of studies does NIH encourage under this FOA?
The FOA highlights several Stage I treatment development categories, including Stage I intervention generation (creating a new intervention or meaningfully adapting an existing one) and Stage I pilot/feasibility research (testing deliverability, engagement, workable procedures, and reliable outcome measurement).
What is "Stage I intervention generation"?
It is the initial creation of a new intervention or a meaningful adaptation of an existing intervention to a new population, setting, or delivery format.
What is meant by adapting an existing intervention?
The FOA frames adaptation as modifying an intervention in a meaningful way so it can be used with a different population, in a different setting, or through a different delivery format.
What is included in Stage I pilot or feasibility research?
These studies focus on whether an intervention can be delivered as intended, whether participants will enroll and stay engaged, whether the procedures are workable, and whether outcome measures can be collected reliably.
Does this FOA emphasize understanding how and why an intervention works?
Yes. The FOA encourages applicants to develop and test putative moderators, mediators, and other candidate mechanisms of change.
What are "moderators" in the context of this FOA?
Moderators are factors that influence for whom an intervention works or under what conditions it works.
What are "mediators" in the context of this FOA?
Mediators are variables that help explain the pathway from an intervention to an outcome.
Does the FOA support work specific to drug abuse treatment and adherence interventions?
Yes. The FOA calls out Stage I studies aimed at generating or refining drug abuse treatment and adherence interventions.
Does the FOA encourage research on improving implementability?
Yes. The FOA includes Stage I research focused on strengthening intervention effects and increasing implementability, including creative use of technology or other methods to improve scalability and adoption in real-world settings.
What does "implementability" mean here?
In this FOA, implementability refers to making interventions easier to deliver, more scalable, and more likely to be adopted in real clinical or community settings.
What types of organizations are eligible to apply?
Eligibility is broad. Eligible applicants include many government entities, higher education institutions (public/state-controlled and private), nonprofits (with or without 501(c)(3) status in the categories listed), for-profit organizations (other than small businesses), small businesses, and an "other" category.
Are state and local governments eligible?
Yes. Eligible government applicants include state, county, city, township, special district governments, and other listed public entities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized Native American tribal governments and other tribal organizations.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are listed among eligible applicants.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofits eligible?
Yes. The FOA includes nonprofits with or without 501(c)(3) status in the specified nonprofit categories (excluding institutions of higher education in those specific nonprofit categories).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also eligible.
Are U.S. territories or possessions eligible?
Yes. The FOA specifically mentions U.S. territories or possessions among eligible groups/settings.
Are foreign (non-U.S.) entities eligible to apply?
Yes. The FOA explicitly includes non-U.S. (foreign) entities among eligible applicants.
Does the FOA highlight participation by certain institution types?
Yes. The FOA specifically highlights Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Historically Black Colleges and Universities (HBCUs); Hispanic-serving Institutions; Tribally Controlled Colleges and Universities (TCCUs); and faith-based or community-based organizations, among others.
What funding category is this opportunity associated with?
The opportunity aligns with the education and health funding category.
What CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.273 and 93.279.
What was the closing date shown for this posting?
The record shows an original closing date of 2019-01-07.
What creation date is shown in the source data?
The record shows a creation date of 2017-11-02.
What is the overall "best fit" for this opportunity?
This opportunity is best suited to small, focused projects that can be completed within two years and that aim to develop, adapt, and pilot behavioral or integrative interventions in the FOA’s targeted areas, including work on mechanisms of change and practical implementation.
Browse more opportunities from the same category: Education, Health
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Previous opportunity: Accelerating the Pace of Drug Abuse Research Using Existing Data (R01 Clinical Trial Optional)
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 18 074) also looked into and applied for these:
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| Clinical Development of Minimally-Invasive Bioassays to Support Outpatient Clinical Trials of Therapeutics for Substance Use Disorders (R21 Clinical Trial Optional) Apply for PA 18 075 Funding Number: PA 18 075 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Examination of Survivorship Care Planning Efficacy and Impact (R01 Clinical Trial Optional) Apply for PA 18 002 Funding Number: PA 18 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Outcomes in Cancer Treatment-Related Cardiotoxicity (R01 Clinical Trial Optional) Apply for PA 18 003 Funding Number: PA 18 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Outcomes in Cancer Treatment-Related Cardiotoxicity (R21 Clinical Trial Optional) Apply for PA 18 013 Funding Number: PA 18 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Prescription Drug Abuse (R21 Clinical Trial Optional) Apply for PA 18 076 Funding Number: PA 18 076 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Clinical Development of Minimally-Invasive Bioassays to Support Outpatient Clinical Trials of Therapeutics for Substance Use Disorders (R01 Clinical Trial Optional) Apply for PA 18 056 Funding Number: PA 18 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Prescription Drug Abuse (R01 Clinical Trial Optional) Apply for PA 18 058 Funding Number: PA 18 058 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Physical Activity and Weight Control Interventions Among Cancer Survivors: Effects on Biomarkers of Prognosis and Survival (R21 Clinical Trial Optional) Apply for PAR 18 016 Funding Number: PAR 18 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Physical Activity and Weight Control Interventions Among Cancer Survivors: Effects on Biomarkers of Prognosis and Survival (R01 Clinical Trial Optional) Apply for PAR 18 006 Funding Number: PAR 18 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R21 Clinical Trial Optional) Apply for PA 18 015 Funding Number: PA 18 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Neuroscience Research on Drug Abuse (R01 Clinical Trial Optional) Apply for PA 18 060 Funding Number: PA 18 060 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Research Specialist (Laboratory-based Scientist) Award (R50) Apply for PAR 18 341 Funding Number: PAR 18 341 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Research Specialist (Core-based Scientist) Award (R50) Apply for PAR 18 342 Funding Number: PAR 18 342 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Oral Anticancer Agents: Utilization, Adherence, and Health Care Delivery (R01 Clinical Trial Optional) Apply for PA 18 004 Funding Number: PA 18 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R01 Clinical Trial Optional) Apply for PA 18 005 Funding Number: PA 18 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Oral Anticancer Agents: Utilization, Adherence, and Health Care Delivery (R21 Clinical Trial Optional) Apply for PA 18 014 Funding Number: PA 18 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Marijuana, Prescription Opioid, or Prescription Benzodiazepine Drug Use Among Older Adults (R03 Clinical Trial Optional) Apply for PA 18 080 Funding Number: PA 18 080 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Prevention Research in Mid-Life Adults (R01 Clinical Trial Optional) Apply for PA 18 134 Funding Number: PA 18 134 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Neuroscience Research on Drug Abuse (R21 Clinical Trial Optional) Apply for PA 18 078 Funding Number: PA 18 078 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Marijuana, Prescription Opioid, or Prescription Benzodiazepine Drug Use Among Older Adults (R21 Clinical Trial Optional) Apply for PA 18 079 Funding Number: PA 18 079 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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