Opportunity Information: Apply for RFA IP 21 003
The grant opportunity titled "Collaborative Research on Influenza, Coronavirus Disease 2019 (COVID-19), and Other Respiratory Pathogens in South Africa" is a CDC funding announcement designed to support targeted research on major respiratory viral threats in South Africa. Issued by the U.S. Department of Health and Human Services through the Centers for Disease Control and Prevention (CDC), it focuses on generating practical, high-value evidence about how influenza, COVID-19, and other respiratory pathogens spread, who they affect most severely, and what factors increase the risk of hospitalization or death. The overall aim is not simply academic knowledge, but data that can directly guide public health decision-making and help South Africa prioritize interventions for populations at highest risk.
This opportunity is structured as a cooperative agreement, meaning CDC expects to play an active role in the supported work rather than acting only as a passive funder. The project is intended to be carried out in collaboration with South Africa's National Institute for Communicable Diseases (NICD). The CDC offices leading the effort are the National Center for Immunization and Respiratory Diseases (NCIRD) and the Center for Global Health (CGH), reflecting a blend of technical respiratory disease expertise and global public health programming. The research emphasis includes epidemiology and disease burden measurement (such as how common these infections are and how severe their impacts are), transmission dynamics (how infections move through communities or specific settings), and analysis of risk factors that predict severe outcomes, particularly for influenza and COVID-19.
A central deliverable implied by the announcement is actionable surveillance and study data that can be translated into policy and program choices. By identifying which groups are most likely to be hospitalized or die from respiratory viral infections, the work can support more strategic use of vaccines, clinical prevention tools, outbreak response resources, and other interventions. The NOFO explicitly highlights the need to inform prioritization of public health interventions in high-risk populations in South Africa, which typically includes people with underlying medical conditions, older adults, pregnant people, individuals living with immunocompromising conditions, and communities with limited access to timely care, though the specific priority groups would be defined through the research findings and local context.
Administratively, the funding opportunity number is RFA IP 21 003 and it falls under the discretionary grant category. The activity area is health, with CFDA numbers 93.083 and 93.326 attached to the program. The CDC anticipated making one award, with an award ceiling of $1,250,000, indicating a single, focused partnership rather than a broad multi-site competition. The announcement was created on December 30, 2020, and the original application closing date was March 9, 2021, with electronic submissions due by 5:00 p.m. Eastern Time on the due date. Eligibility is listed as "Others" with clarification referenced in an additional eligibility section, but the text of the announcement makes clear that CDC sought to initiate the cooperative agreement specifically with NICD in South Africa, consistent with a highly targeted collaboration model.
In practical terms, this funding announcement supports a coordinated, CDC-NICD research effort to strengthen understanding of respiratory virus impacts in South Africa across seasons and waves, quantify the real burden on health systems and communities, and clarify the pathways and predictors of severe disease. The expected payoff is better targeting of prevention and response measures, grounded in local evidence, to reduce illness and death from influenza, COVID-19, and other respiratory pathogens.Apply for RFA IP 21 003
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Collaborative Research on Influenza, Coronavirus Disease 2019 (COVID-19), and Other Respiratory Pathogens in South Africa" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.083, 93.326.
- This funding opportunity was created on Dec 30, 2020.
- Applicants must submit their applications by Mar 09, 2021 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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