Opportunity Information: Apply for PAS 18 698
The High Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional) opportunity, numbered PAS-18-698, is a National Institutes of Health (NIH) discretionary grant announcement designed to expand and strengthen HIV/AIDS research that clearly fits within the scientific scope of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The central purpose is to stimulate studies that respond to the NIH Office of AIDS Research (OAR) high-priority HIV/AIDS research priorities, as laid out in NOT-OD-15-137, which provides the NIH-wide guidelines for what qualifies as AIDS-designated funding and the priority areas NIH is aiming to advance. In practical terms, this means proposed projects need to be both (1) strongly aligned with NIDDK mission areas such as diabetes, endocrinology and metabolism, digestive diseases, nutrition, obesity, kidney/urologic/hematologic diseases, and related complications, and (2) meaningfully connected to HIV/AIDS research priorities defined by OAR.
The funding mechanism is an NIH Research Project Grant (R01), which is typically used to support mature, hypothesis-driven research programs with a substantial scientific scope. The FOA is listed as “Clinical Trial Optional,” meaning applicants may propose either clinical trial research or non-clinical-trial research, as long as the project meets NIH definitions and requirements. This flexibility is important for HIV-related work within NIDDK’s areas because some high-impact questions can be addressed through observational studies, mechanistic laboratory research, translational studies, implementation approaches, or interventional clinical trials depending on the topic and readiness of the field.
This announcement sits in the broader NIH funding activity category associated with health and food/nutrition (CFDA 93.847), reflecting NIDDK’s emphasis on metabolism, nutrition, and organ-system diseases, and how HIV infection, antiretroviral therapy, and co-morbid conditions intersect with these areas. While the FOA text provided does not list a specific award ceiling or an expected number of awards, applicants should generally interpret R01 support as substantial but competitively awarded based on scientific merit, program relevance, and available appropriations. The original closing date shown is January 7, 2021, and the FOA creation date is March 5, 2018, which are useful for understanding the historical timeframe of the announcement and for checking whether NIH has reissued, updated, or replaced it with a newer iteration.
A notable feature of this opportunity is the broad eligibility. Beyond the standard range of U.S. applicant organizations (including state, county, and local governments; special districts; independent school districts; and public housing authorities), it is open to public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations other than small businesses, and small businesses. It also explicitly highlights eligibility for a wide set of mission-relevant and equity-focused institution types and community-linked organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). In addition, it includes faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-domestic (non-U.S.) entities (foreign organizations). This broad eligibility signals NIH’s intent to encourage diverse applicants and settings, including those serving populations disproportionately affected by HIV and its metabolic, renal, gastrointestinal, nutritional, and endocrine complications.
Overall, this FOA is best understood as an NIH/NIDDK pathway for investigators to pursue high-priority HIV/AIDS research questions that sit at the intersection of HIV and NIDDK-relevant diseases and systems, while also aligning with NIH-wide OAR priorities for AIDS-designated research. Applicants would be expected to make a clear case that their proposed aims advance HIV/AIDS science and directly map to NIDDK’s mission areas, whether through basic mechanisms, translational pathways, clinical investigations, or (optionally) clinical trials, using the R01 framework to support a rigorous, well-justified research plan.Apply for PAS 18 698
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "High Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2018-03-05.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: High Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional) - PAS-18-698
What is PAS-18-698?
PAS-18-698 is a National Institutes of Health (NIH) discretionary funding opportunity announcement (FOA) titled "High Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional)." It is intended to expand and strengthen HIV/AIDS research that clearly fits within the scientific scope of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Which NIH institute is associated with this FOA?
This FOA is within the mission and scientific scope of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the main purpose of this funding opportunity?
The central purpose is to stimulate research studies that respond to the NIH Office of AIDS Research (OAR) high-priority HIV/AIDS research priorities, while also being strongly aligned with NIDDK mission areas.
What kind of research does NIDDK expect under this opportunity?
Projects should sit at the intersection of HIV/AIDS and NIDDK-relevant diseases and systems. The FOA emphasizes research that is both meaningfully connected to HIV/AIDS priorities and clearly within NIDDK scientific areas such as diabetes, endocrinology and metabolism, digestive diseases, nutrition, obesity, kidney/urologic/hematologic diseases, and related complications.
What are the key alignment requirements for a proposed project?
Based on the FOA description, proposed projects should meet two alignment expectations:
- Strong alignment with NIDDK mission areas (for example: diabetes, metabolism, digestive diseases, nutrition/obesity, kidney/urologic/hematologic diseases, and related complications).
- Meaningful connection to NIH Office of AIDS Research (OAR) high-priority HIV/AIDS research priorities.
What is the funding mechanism for PAS-18-698?
The mechanism is an NIH Research Project Grant (R01). R01 awards are commonly used to support mature, hypothesis-driven research programs with substantial scientific scope.
Is this FOA limited to clinical trials?
No. The FOA is listed as "Clinical Trial Optional," meaning applicants may propose either clinical trial research or non-clinical-trial research, as long as the project meets NIH definitions and requirements.
If clinical trials are optional, what other study types fit this FOA?
The FOA description indicates that, depending on the topic, readiness, and research question, relevant approaches may include observational studies, mechanistic laboratory research, translational studies, implementation approaches, or interventional clinical trials.
How does this FOA connect to NIH-wide HIV/AIDS priorities?
This opportunity is intended to stimulate studies that respond to OAR high-priority HIV/AIDS research priorities. These priorities are described as being laid out in NOT-OD-15-137, which provides NIH-wide guidelines for what qualifies as AIDS-designated funding and the priority areas NIH is aiming to advance.
What is NOT-OD-15-137 and why is it relevant here?
NOT-OD-15-137 is described as the NIH-wide guidance that outlines what qualifies as AIDS-designated funding and the high-priority HIV/AIDS research areas NIH is aiming to advance. The FOA expects projects to respond to those OAR priorities.
What is the CFDA number associated with this opportunity?
The FOA is associated with CFDA 93.847, described as reflecting a broader NIH funding activity category tied to health and food/nutrition, consistent with NIDDK emphases such as metabolism, nutrition, and organ-system diseases.
Does the FOA specify an award ceiling or the expected number of awards?
The provided FOA summary does not list a specific award ceiling or an expected number of awards. It indicates applicants should generally interpret R01 support as substantial but competitively awarded based on scientific merit, program relevance, and available appropriations.
What factors are highlighted as influencing whether an R01 is awarded under this FOA?
The FOA description highlights competitive award decisions based on scientific merit, program relevance, and available appropriations.
What are the key dates mentioned for this FOA?
The FOA creation date is March 5, 2018, and the original closing date shown is January 7, 2021.
Why do the creation and closing dates matter?
These dates help establish the historical timeframe of the announcement and are useful for checking whether NIH has reissued, updated, or replaced the FOA with a newer iteration.
Who is eligible to apply for PAS-18-698?
The FOA description indicates broad eligibility, including many U.S. organization types as well as non-U.S. entities. Eligible applicants include:
- State, county, and local governments
- Special districts
- Independent school districts
- Public housing authorities
- Public and private institutions of higher education
- Nonprofits with or without 501(c)(3) status
- For-profit organizations other than small businesses
- Small businesses
- Eligible federal agencies
- U.S. territories or possessions
- Regional organizations
- Non-domestic (non-U.S.) entities (foreign organizations)
Are minority-serving institutions specifically included in eligibility?
Yes. The FOA explicitly highlights eligibility for several types of institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The FOA description explicitly includes faith-based or community-based organizations among eligible applicants.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA description indicates that non-domestic (non-U.S.) entities (foreign organizations) are eligible.
What HIV-related topics are implied to be especially relevant to NIDDK?
The description emphasizes intersections where HIV infection, antiretroviral therapy, and co-morbid conditions relate to NIDDK-relevant areas such as metabolic disease, nutrition, digestive diseases, endocrine complications, kidney/urologic issues, and hematologic diseases.
What should an applicant emphasize to demonstrate fit with this FOA?
Applicants would be expected to make a clear case that their proposed aims advance HIV/AIDS science, directly map to NIDDK mission areas, and respond to NIH OAR high-priority HIV/AIDS research priorities, using an R01-appropriate, rigorous, and well-justified research plan.
Does the FOA favor basic science, translational research, or clinical research?
The FOA description indicates that relevant work may range across basic mechanisms, translational pathways, clinical investigations, and (optionally) clinical trials, as long as the project aligns with both OAR HIV/AIDS priorities and NIDDK mission areas.
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| New Directions in Hematology Research (SHINE-II) (R01 Clinical Trial Optional) Apply for PAS 18 730 Funding Number: PAS 18 730 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21 Clinical Trial Not Allowed) Apply for PA 18 741 Funding Number: PA 18 741 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Mechanisms Underlying the Contribution of Type 1 Diabetes Disease-associated Variants (R01 Clinical Trial Not Allowed) Apply for RFA DK 18 005 Funding Number: RFA DK 18 005 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| Pilot and Feasibility Clinical Research Grants in Urologic Disorders (R21 Clinical Trial Optional) Apply for PAR 18 743 Funding Number: PAR 18 743 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Pilot and Feasibility Clinical Research Grants in Kidney Diseases (R21 Clinical Trial Optional) Apply for PAR 18 744 Funding Number: PAR 18 744 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Understanding Skeletal Effects of Type 1 Diabetes (R01 Clinical Trial Optional) Apply for RFA DK 18 002 Funding Number: RFA DK 18 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $400,000 |
| Regenerative Medicine Innovation Projects (RMIP) (U44 - Clinical Trial Not Allowed) Apply for RFA HL 18 035 Funding Number: RFA HL 18 035 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| Regenerative Medicine Innovation Projects (RMIP) Investigator-Initiated Studies (Collaborative U01 Clinical Trial Not Allowed) Apply for RFA HL 18 030 Funding Number: RFA HL 18 030 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Regenerative Medicine Innovation Projects (RMIP) (UT2 - Clinical Trial Not Allowed) Apply for RFA HL 18 033 Funding Number: RFA HL 18 033 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| Regenerative Medicine Innovation Projects (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Apply for RFA HL 18 031 Funding Number: RFA HL 18 031 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $405,000 |
| New Paradigms in Tissue Communication-from mediators to metabolic function (RC2 Clinical Trials Optional) Apply for PAR 18 886 Funding Number: PAR 18 886 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of Novel Tools and Methodologies (RC2 Clinical Trial Optional) Apply for PA 18 891 Funding Number: PA 18 891 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Elucidating the Role of the Autonomic Nervous System in Peripheral Metabolism and Metabolic Disease through the Application of Novel Tools and Methodologies (RC2 Clinical Trial Optional) Apply for PAR 18 898 Funding Number: PAR 18 898 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA DK 18 011 Funding Number: RFA DK 18 011 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21 Clinical Trial Optional) Apply for PA 18 903 Funding Number: PA 18 903 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Limited Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Centers (U01 Clinical Trial Required) Apply for RFA DK 18 505 Funding Number: RFA DK 18 505 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,000,000 |
| Limited Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center (U24 Clinical Trial Required) Apply for RFA DK 18 506 Funding Number: RFA DK 18 506 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $2,000,000 |
| Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Data Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DK 18 504 Funding Number: RFA DK 18 504 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Participating Clinical Centers (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 503 Funding Number: RFA DK 18 503 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Sites (U01 Clinical Trial Not Allowed) Apply for RFA DK 18 513 Funding Number: RFA DK 18 513 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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