Opportunity Information: Apply for RFA DA 19 013
The grant opportunity "Responding to Opioid Use Disorders (OUD) in Tribal Communities in the Context of SAMHSA and CDC Funding (R61/R33 - Clinical Trials Optional)" (Funding Opportunity Number RFA-DA-19-013) is a discretionary NIH grant designed to strengthen and expand tribal responses to the opioid crisis by building directly on work already supported through SAMHSA opioid-related awards. In practical terms, the FOA is meant to take programs and service activities that tribal communities are already operating with SAMHSA support (including TI-18-016, TI-18-015, and TI-17-014) and add a strong research component that is culturally relevant, community-grounded, and capable of producing usable evidence about what works, for whom, and under what conditions in tribal settings. Although the title references SAMHSA and CDC funding context, the administering agency listed is the National Institutes of Health, and the overall focus is on research that improves prevention, treatment, and implementation strategies for OUD in tribal communities.
The research topics are intentionally flexible because the underlying SAMHSA-funded activities differ across tribal communities. Applicants are encouraged to propose studies that match the realities of their local opioid response and that can produce rigorous, actionable findings without forcing a one-size-fits-all model. Examples of appropriate projects include adapting evidence-based interventions so they are more feasible and acceptable in tribal communities, improving availability and real-world effectiveness of those interventions, and evaluating whether interventions proven in other populations still work well when implemented in tribal contexts. The FOA also supports adding hypothesis-driven data collection that can guide thoughtful adaptation and implementation, as well as epidemiologic and implementation-focused studies that examine reach, uptake, fidelity, barriers, facilitators, and overall impact of opioid-related interventions. Clinical trials are optional, meaning applicants can propose a clinical trial if it fits the aims, but a trial is not required to be competitive.
A core feature of the FOA is its two-phase structure using the R61/R33 mechanism. The first phase (R61) can support up to two years and functions as a development and start-up period. This phase is intended for foundational work that makes a larger study possible and credible, such as refining the study design, establishing recruitment and retention procedures, developing or validating measurement approaches, building data systems, and, when relevant, adapting an intervention so it aligns with local culture, community priorities, and service delivery settings. The R61 phase can also include pilot testing key elements to reduce risk before launching a larger study. Importantly, investigators must define clear, pre-specified milestones for the R61 period, and progress toward those milestones is used to determine whether the project is ready to move forward.
The second phase (R33) can provide up to three additional years of support, but it is not automatic. Transition to the R33 depends on successful completion of the R61 phase milestones and an approved plan for the full-scale R33 research activities. Conceptually, the R33 phase is where the project expands into a more complete test of the research aims, such as a larger effectiveness evaluation, a more definitive implementation study, or a broader epidemiologic assessment of intervention reach and outcomes. This phased approach is designed to ensure that early-stage development work genuinely informs the larger study and that the later-stage effort is feasible, well-designed, and ready to generate meaningful evidence.
Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also explicitly calls out additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, historically Black colleges and universities, tribally controlled colleges and universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, tribal governments other than federally recognized, and U.S. territories or possessions. At the same time, foreign organizations and foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed.
From an administrative standpoint, the opportunity is categorized under Education and Health (CFDA 93.279). The original closing date listed is 2018-11-29, and the opportunity was created on 2018-09-18. The award ceiling is listed as $500,000. The FOA frames this funding as a way to turn ongoing tribal opioid response work into stronger, evidence-producing efforts that can guide future decisions, improve service delivery, and better reflect the cultural and practical realities of tribal communities addressing opioid use disorders.Apply for RFA DA 19 013
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Responding to Opioid Use Disorders (OUD) in Tribal Communities in the Context of SAMHSA and CDC Funding (R61/R33 - Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2018-09-18.
- Applicants must submit their applications by 2018-11-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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